ART-TG : Laureate EIC for TREM2MEDS

We are thrilled to announce that ART-TG will be showcased by Inserm (the French National Institute of Health and Medical Research) for its participation in the groundbreaking European Innovation Council (EIC) research project TREM2MEDS. The project will be presented on March 13th, 2026 (9h00-14h00) at the Paris Santé Campus 2-10 rue d'Ouradour-sur-glane Paris 75015.

ART-TG participates as a partner within the TREM2MEDS consortium led by Prof. Alessandra Biffi from UNIPD (University of Padova) and includes teams from several European institutions. This recognition highlights the international recognition of the scientific excellence and collaborative impact of ART-TG contribution.

About the TREM2MEDS Project

The TREM2MEDS project — “Towards the clinical implementation of TREM2 Microglia Engineering for treating DementiaS” — is an EU-funded research initiative under the European Innovation Council (EIC), that intends to develop towards early phase clinical testing an innovative gene therapy strategy proposed for the treatment of Alzheimer’s disease (AD) and AD-like dementias.

The project focuses on microglia, the immune cells of the brain, and a protein called TREM2 (Triggering Receptor Expressed on Myeloid Cells 2). In healthy brains, microglia help clear toxic protein deposits and support tissue health. When TREM2 function is impaired, this cleanup process becomes less effective, contributing to the progression of dementia.

The TREM2MEDS approach uses advanced gene-based techniques to enhance TREM2 function in microglia, helping these cells:

• restoring microglia function towards plaque, debris and neurofilament tangle removal

• reducing neuroinflammation by elevating cellular TREM2 expression

This approach represents a competitive solution for patients affected by AD and AD-like dementia NHD.

More informations : https://trem2meds.eu

Linkedin : https://www.linkedin.com/company/trem2meds/

Reference : Milazzo R, Montepeloso A, Kumar R, Ferro F, Cavalca E, Rigoni P, Cabras P, Ciervo Y, Das S, Capotondo A, Pellin D, Peviani M, Biffi A. Therapeutic efficacy of intracerebral hematopoietic stem cell gene therapy in an Alzheimer's disease mouse model. Nat Commun. 2024 Sep 13;15(1):8024. doi: 10.1038/s41467-024-52301-w. PMID: 39271711; PMCID: PMC11399302.